Salmon Sperm Facials: What PDRN & Rejuran Actually Do for Skin
The “salmon sperm facial” is real — sort of. The ingredient is PDRN, purified DNA fragments sourced from salmon, and it's the engine behind Korea's Rejuranskin booster. Applied with microneedling so it reaches the skin, PDRN supports repair, hydration, and collagen — the “glass skin” effect the internet can't stop talking about. At Neoderma in Anaheim, Rejuran starts at $1,055 for 2 mL.
Medically reviewed by Sal Nadkarni, DO · Last updated July 22, 2026
Why is everyone talking about salmon sperm?
Blame Korea first, celebrities second. PDRN treatments have been a staple of Korean aesthetic clinics for years, and once stars like Kim Kardashian and Jennifer Aniston talked publicly about “salmon sperm facials,” U.S. searches exploded. Beauty editors now rank PDRN among the biggest skincare ingredients of 2026, part of a larger shift toward regenerative aesthetics — treatments that help skin repair itself rather than just filling or freezing it.
What is PDRN — and is it really from salmon?
Yes. PDRN (polydeoxyribonucleotide) is a chain of purified DNA fragments extracted from salmon — chosen because salmon DNA is remarkably compatible with human skin and can be purified to medical grade. There are no sperm cells in the vial; the DNA is fragmented, sterilized, and refined into a clear, medical-grade ingredient. In the skin, those nucleotide fragments act like building material and a repair signal at once: research suggests PDRN supports cell regeneration, calms inflammation, improves microcirculation, and stimulates collagen — which is why it shows up in everything from Korean skin boosters to wound-care medicine.
PDRN serums vs. in-office Rejuran
Here's the part the viral videos skip: how PDRN gets into your skin matters more than the ingredient itself. DNA fragments are large molecules, so a serum mostly conditions the surface. Rejuran places polynucleotides where repair actually happens.
| PDRN serum | Rejuran (in-office) | |
|---|---|---|
| How it's delivered | Applied to the surface at home | Applied during microneedling — micro-channels carry it in |
| Where the PDRN goes | Mostly stays on top — large molecules penetrate poorly | Placed in the skin, where repair actually happens |
| What to expect | Hydration, a dewy finish, mild calming | Firmer, smoother, more elastic skin over a series |
| Best for | Daily maintenance between treatments | Under-eyes, fine lines, texture, crepey skin |
| Typical cost | $30–$100 per bottle | From $1,055 per 2 mL session at Neoderma |
Serums are a fine complement between visits — we just want you to know what each can and can't do before you spend.
Rejuran at Neoderma: what it treats
Rejuran is a Korean polynucleotide (“PN”) skin booster — applied to the skin in conjunction with microneedling — the micro-channels carry it in — to improve skin quality from within: hydration, elasticity, fine lines, and texture. It's especially loved for the under-eye area, where thin, crepey skin and dark circles make filler a clumsy tool. It is not a filler — it doesn't add volume — and that's exactly the point: it makes the skin itself healthier over a short series of sessions, with results that build for weeks afterward.
Prefer needle-free? Our K-BioGlow Korean Radiance Ritual delivers the Korean glass-skin approach as a 4-step facial — spicule exfoliation, collagen infusion, LED, and a luxury mask — currently $375 (50% off) for first-time clients through July 31.
What does it cost in Anaheim?
Rejuran starts at $1,055 for 2 mL, typically over a short series spaced a few weeks apart — you'll get an exact plan at your consultation. That's in line with what Korean-trained clinics charge for authentic Rejuran, and far below what many Beverly Hills practices ask for the same product.
Financing available through Cherry and CareCredit — split your treatment into flexible monthly payments. Learn more →
PDRN & Rejuran FAQ
What is a salmon sperm facial, really?
It's the nickname for treatments built on PDRN (polydeoxyribonucleotide) — purified, fragmented DNA sourced from salmon. There are no actual sperm cells involved; the DNA fragments are extracted, sterilized, and purified into a regenerative ingredient. Delivered into the skin, PDRN supports tissue repair, hydration, and collagen production. The best-known version is Rejuran, the Korean polynucleotide skin booster.
Is Rejuran the same as the salmon sperm serums I see online?
Same ingredient family, very different delivery. Topical PDRN serums sit on the surface, where the large DNA molecules have limited ability to penetrate — they hydrate and calm, but effects are modest. At Neoderma, Rejuran is applied to the skin in conjunction with microneedling: the micro-channels carry the polynucleotides into the skin, where they can actually support repair and collagen — which is why in-office results are in a different league from a serum.
What does Rejuran help with?
Skin quality from within: hydration, elasticity, fine lines, texture, and overall resilience. It's especially popular for the under-eye area — crepey skin and dark circles — where fillers can look heavy. It's not a filler and doesn't add volume; it improves the quality of the skin itself over a short series of sessions.
How much does Rejuran cost at Neoderma in Anaheim?
Rejuran starts at $1,055 for 2 mL, typically done as a short series of sessions spaced a few weeks apart. You'll get an exact plan and quote at your consultation, and financing is available through Cherry and CareCredit.
Is PDRN safe? Are there side effects?
PDRN has been used in Korean and European aesthetic medicine for years and has a strong safety record — it's biocompatible and non-animal-protein allergenic for most people. Because Rejuran is applied with microneedling, expect temporary redness and mild sensitivity in the treated area for a day or so — similar to any microneedling session. We review your history first, and anything notable is reviewed by our medical team before treatment.
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